diff --git a/test/c_abi/main.zig b/test/c_abi/main.zig
index 10cdab85b7..f2b1b5014b 100644
--- a/test/c_abi/main.zig
+++ b/test/c_abi/main.zig
@@ -1182,6 +1182,7 @@ test "big simd vector" {
     if (builtin.cpu.arch.isPowerPC64()) return error.SkipZigTest;
     if (builtin.cpu.arch.isLoongArch()) return error.SkipZigTest;
     if (builtin.zig_backend == .stage2_llvm and builtin.cpu.arch == .x86_64 and builtin.os.tag.isDarwin() and builtin.mode != .Debug) return error.SkipZigTest;
+    if (builtin.cpu.arch == .s390x) return error.SkipZigTest;
 
     c_big_vec(.{ 1, 2, 3, 4, 5, 6, 7, 8 });