diff --git a/src/Compilation.zig b/src/Compilation.zig
index d6157fec82..177c71f4d1 100644
--- a/src/Compilation.zig
+++ b/src/Compilation.zig
@@ -4457,9 +4457,18 @@ pub fn addCCArgs(
             if (comp.sanitize_c and !comp.bin_file.options.tsan) {
                 try argv.append("-fsanitize=undefined");
                 try argv.append("-fsanitize-trap=undefined");
+                // It is very common, and well-defined, for a pointer on one side of a C ABI
+                // to have a different but compatible element type. Examples include:
+                // `char*` vs `uint8_t*` on a system with 8-bit bytes
+                // `const char*` vs `char*`
+                // `char*` vs `unsigned char*`
+                // Without this flag, Clang would invoke UBSAN when such an extern
+                // function was called.
+                try argv.append("-fno-sanitize=function");
             } else if (comp.sanitize_c and comp.bin_file.options.tsan) {
                 try argv.append("-fsanitize=undefined,thread");
                 try argv.append("-fsanitize-trap=undefined");
+                try argv.append("-fno-sanitize=function");
             } else if (!comp.sanitize_c and comp.bin_file.options.tsan) {
                 try argv.append("-fsanitize=thread");
             }